ea0065oc5.4 | Adrenal and Cardiovascular | SFEBES2019
Martin Claire
, Fenton Chloe
, Filer Andrew
, Hewison Martin
, Clark Andy
, Hardy Rowan
The glucocorticoid (GC) activating enzyme 11β-HSD1 is potently upregulated within macrophages and synovial fibroblasts of inflamed joints, where it increases therapeutic GC signalling and regulates their anti-inflammatory profiles. Whilst in vitro studies have demonstrated the importance of autocrine signalling in this context, the importance of paracrine signalling remains poorly defined. In this study, we examined the role of 11β-HSD1 in paracrine GC signalling bet...